Diamandas, Matthew; Moreira, Ryan; Taylor, Scott D. published the artcile< Solid-phase total synthesis of dehydrotryptophan-bearing cyclic peptides tunicyclin B, sclerotide A, CDA3a, and CDA4a using a protected β-hydroxytryptophan building block>, Safety of Triphenylmethanol, the main research area is cyclic peptide dehydrotryptophan solid phase total synthesis antibacterial agent; tunicyclin B sclerotide A CDA3a CDA4a hydroxytryptophan protected.
A new approach to the synthesis of Z-dehydrotryptophan (ΔTrp) peptides is described. This approach uses Fmoc-β-HOTrp(Boc)(TBS)-OH as a building block, which is readily prepared in high yield and incorporated into peptides using solid-phase Fmoc chem. The tert-butyldimethylsilyl-protected indolic alc. is eliminated during global deprotection/resin cleavage to give ΔTrp peptides exclusively as the thermodynamically favored Z isomer. This approach was applied to the solid-phase synthesis of tunicyclin B, sclerotide A, CDA3a, and CDA4a.
Organic Letters published new progress about Antibacterial agents. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.
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