Ferreira, Joana T.; Pina, Joao; Ribeiro, Carlos A. F.; Fernandes, Rosa; Tome, Joao P. C.; Rodriguez-Morgade, M. Salome; Torres, Tomas published the artcile< Highly Efficient Singlet Oxygen Generators Based on Ruthenium Phthalocyanines: Synthesis, Characterization and in vitro Evaluation for Photodynamic Therapy>, Quality Control of 4064-06-6, the main research area is glucose galactose mannose ruthenium phthalocyanine preparation photodynamic therapy; carbohydrates; photodynamic therapy; phthalocyanines; ruthenium; singlet oxygen.
The synthesis of ruthenium(II) phthalocyanines (RuPcs) endowed with one carbohydrate unit-i.e., glucose, galactose and mannose-and a dimethylsulfoxide (DMSO) ligand at the two axial coordination sites, resp., is described. Two series of compounds, one unsubstituted at the periphery, and the other one bearing eight PEG chains at the isoindole meta-positions, have been prepared The presence of the axial DMSO unit significantly increases the phthalocyanine singlet oxygen quantum yields, related to other comparable RuPcs. The compounds have been evaluated for PDT treatment in bladder cancer cells. In vitro studies have revealed high phototoxicity for RuPcs unsubstituted at their periphery. The phototoxicity of PEG-substituted RuPcs has been considerably improved by repeated light irradiation The choice of the axial carbohydrate introduced little differences in the cellular uptake for both series of photosensitizers, but the phototoxic effects were considerably higher for compounds bearing mannose units.
Chemistry – A European Journal published new progress about Bladder neoplasm. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Quality Control of 4064-06-6.
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