Wu, Jia-Xue; Yao, Qing-Xia; Duan, Wen-Zeng; Li, Da-Cheng; Huang, Xian-Qiang; Dou, Jian-Min; Wang, Huai-Wei published the artcile< RhIII-Catalyzed heteroarylation of N-2,6-difluorophenyl arylamides with heteroaryl boronate esters>, Formula: C12H18BNO2, the main research area is aryl heteroaryl amide preparation regioselective; difluorophenyl arylamide heteroaryl boronate ester heteroarylation rhodium.
Herein, an efficient strategy to achieve aryl-heteroaryl formation via RhIII-catalyzed ortho-C(sp2)-H heteroarylation of (hetero)arenes with heterocyclic boronates using a readily removable N-2,6-difluorophenyl arylamide directing group has been disclosed. A variety of heteroaromatic boronates as the coupling partners were shown to be able to participate in this protocol, providing the desired heteroarylated products with high reactivity and good tolerance of functional groups. The achievement of this C(sp2)-H heteroarylation could potentially offer a route to synthesize heterocyclic drug mols. in medicinal chem.
Organic Chemistry Frontiers published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Formula: C12H18BNO2.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts