Wang, Ji-Sheng; Feng, Jun-Long; Dai, Heng-Heng; Chen, Zi-Long; Li, Xiao; Bao, Bing-Hao; Deng, Sheng; Meng, Fan-Chao; Zhao, Qi; Xu, Hong-Sheng; Wang, Bin; Li, Hai-Song published the artcile< Potential mechanism of Achyranthis bidentatae radix plus semen vaccariae granules in the treatment of diabetes mellitus-induced erectile dysfunction in rats utilizing combined experimental model and network pharmacology>, Computed Properties of 87-73-0, the main research area is Achyranthis bidentatae semen vaccariae granule DMED treatment network pharmacol; Endocrine diseases; biological network; penis; traditional Chinese medicine.
Achyranthes bidentata Blume (Amaranthaceae) (ABR) and semen vaccariae (SV) are used commonly in the clin. treatment of erectile dysfunction in males with diabetes mellitus (DMED) to strengthen the kidney and promote blood circulation, and often achieve good curative effects. Explore mechanistic details of ABR + SV treatment against DMED. Prediction of key targets by network pharmacol. A rat model of DM was established by streptozotocin injection (55 mg/kg). Apomorphine (100μg/kg) was injected into rats to screen the DMED model. Group C (n = 6) and group M (n = 6) were gavaged with deionized water; group T (n = 6) was given Achyranthis bidentatae radix-semen vaccariae granule suspension (2.5 g/kg). It lasted 8 wk. Real-time reverse transcription-quant. polymerase chain reaction (RT-qPCR) and western blotting (WB) were used to measure the expression of tissue-related proteins and mRNA. The predicted key targets are albumin (ALB), caspase-3 (CASP3), vascular endothelial growth factor A (VEGFA), angiotensin-converting enzyme (ACE), and endothelial nitric oxide synthase (eNOS). Compared with the M group (0.52 ± 0.04; 0.50 ± 0.03; 0.49 ± 0.02; 0.23 ± 0.03), CASP3, VEGFA, and ACE protein expression reduced in the T group (0.39 ± 0.06; 0.34 ± 0.03; 0.39 ± 0.03), and eNOS protein expression increased (0.34 ± 0.03). ABR + SV can improve erectile function in DMED rats. This study provides a potential mechanism for the treatment of DMED with ABR + SV and can benefit from more patients.
Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about Achyranthes bidentata. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Computed Properties of 87-73-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts