Repossi, Gaston; Das, Undurti N.; Eynard, Aldo Renato published the artcile< Molecular Basis of the Beneficial Actions of Resveratrol>, Electric Literature of 501-36-0 , the main research area is review resveratrol gut microbiota transcription factor inflammation; Brain-derived neurotrophic factor; Cancer; Cytotoxic; Lipoxin A4; Metabolic syndrome; Polyunsaturated fatty acids; Resveratrol.
A review. Resveratrol modulates the transcription factor NF-κB, cytochrome P 450 isoenzyme CYP1A1, expression and activity of cyclooxygenase (COX) enzymes, Fas/Fas ligand mediated apoptosis, p53, mTOR and cyclins and various phospho-diesterases resulting in an increase in cytosolic cAMP levels. CAMP, in turn, activates Epac1/CaMKKβ/AMPK/SIRT1/PGC-1α pathway that facilitates increased oxidation of fatty acids, mitochondrial respiration and their biogenesis and gluconeogenesis. Resveratrol triggers apoptosis of activated T cells and suppresses tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17) and other pro-inflammatory mols. and inhibits expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) that may explain its anti-inflammatory actions. We observed that PUFAs (especially arachidonic acid, AA) and BDNF (brain-derived neurotrophic factor) protect against the cytotoxic actions of alloxan, streptozotocin, benzo(a)pyrene (BP) and doxorubicin. Thus, there is an overlap in the beneficial actions of resveratrol, PUFAs and BDNF suggesting that these mols. may interact and augment synthesis and action of each other. Since resveratrol is not easily absorbed from the gut it is likely that it may act on endocannabinoid and light, odor, and taste receptors located in the gut, which, in turn, convey their messages to the various organs via vagus nerve.
Archives of Medical Research published new progress about AMP-activated protein kinase activators. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0 .
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