Synthetic Route of 109-83-1 , The common heterocyclic compound, 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
PREPARATION I; N(2-hydroxyethyl)-4-methoxy-N,2,6-trimethylbenzene-sulphonamide; A solution of 1.76 g (23.4 mM) of 2-(methylamino)ethanol is prepared in 100 ml of DCM and 5.4 g (53 mM) of triethylamine are added. The mixture is cooled to 0 C. and a solution of 5 g (21.3 mM) of 2,6 dimethyl-4-methoxybenzenesulphonyl chloride in 50 ml of DCM is added progressively. The mixture is then agitated for 3 hours at ambient temperature, and then poured over 50 ml of 0.5 N hydrochloric acid. The organic phase is separated and then washed with water, dried over magnesium sulphate and concentrated under reduced pressure. 5.8 g of the compound sought after are thus obtained as a colourless oil (yield=100%). 1H NMR (300 MHz, DMSO) delta: 6.80 (s, 2H); 4.70 (t, 1H); 3.80 (s, 3H); 3.48 (q, 2H); 3.09 (t, 2H); 2.69 (s, 3H); 2.54 (s, 6H).
The synthetic route of 109-83-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Laboratoires Fournier S.A.; US2006/178360; (2006); A1;,
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