In 2022,Fan, You Kun; Feng, Shao Min; Liu, Xi Liang; Li, Kai Qi; Chen, Dong Liang; Xiong, Cheng Dong published an article in Macromolecular Rapid Communications. The title of the article was 《Synthesis and Characterization of Novel Radiopaque Polycarbonate》.Category: alcohols-buliding-blocks The author mentioned the following in the article:
Polymeric materials implanted in the human body are usually invisible under X-ray, and the mixing of heavy metal salts into polymeric materials by phys. compounding often poses compatibility problems. A new iodine-containing cyclic carbonate monomer, 4-iodo-N-(2-oxo-1,3-dioxan-5-yl)benzamide (IBTMC), is synthesized, which has a degradable carbonate group as its basic structural unit and iodine atoms attached to the side chain in the form of covalent bonds. The ring-opening polymerization of IBTMC is achieved at room temperature under the catalysis of the solid superbase 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD). The structure and X-ray developing ability of the synthesized polycarbonate are characterized by 1H-NMR, XPS, energy dispersive X-ray spectroscopy (EDS), Gel Permeation Chromatog. (GPC), and micro-computed tomog. (Micro-CT). The iodine atoms remain bound to the polymer as covalent bonds after a series of reactions and exhibit a high level of X-ray opacity. In vitro degradation experiments of the polymer prove that the polymer is degradable. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Category: alcohols-buliding-blocks)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts