Application of 10029-04-6 ,Some common heterocyclic compound, 10029-04-6, molecular formula is C6H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Ethyl 2-(hydroxymethyl)acrylate 3 (1470 mg, 11.31 mmol), triphenylphosphine (3259 mg, 12.44 mmol) and BocNHTos (3360 mg, 12.44 mmol) were dissolved in dry THF (110 mL). Diisopropyl azodicarboxylate (2512 mg, 12.44 mmol) was slowly added at 0 C and the reaction mixture was stirred at room temperature for 24 h. Evaporation of the solvent and purification by flash chromatography on silica gel (petroleum ether/EtOAc 9:1) afforded pure compound 4.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10029-04-6, its application will become more common.
Reference:
Article; ?ukauskaite, Asta; Mangelinckx, Sven; Callebaut, Gert; Wybon, Clarence; ?a?kus, Algirdas; De Kimpe, Norbert; Tetrahedron; vol. 69; 16; (2013); p. 3437 – 3443;,
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