Product Details of 89466-08-0In 2020 ,《Discovery of a Potent Anticancer Agent PVHD303 with in Vivo Activity》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Suzuki, Yumiko; Otake, Ayana; Ueno, Satoshi; Hayashi, Kensuke; Ishii, Hirosuke; Miyoshi, Nao; Kuroiwa, Kenta; Tachikawa, Masashi; Fujimaki, Yuki; Nishiyama, Kotaro; Manabe, Kei; Yamazaki, Ryuta; Asai, Akira. The article conveys some information:
As a part of our continuous structure-activity relationship (SAR) studies on 1-(quinazolin-4-yl)-1-(4-methoxyphenyl)ethan-1-ols, the synthesis of derivatives and their cytotoxicity against the human lung cancer cell line A549 were explored. This led to the discovery of 1-(2-(furan-3-yl)quinazolin-4-yl)-1-(4-methoxyphenyl)ethan-1-ol (PVHD303) with potent antiproliferative activity. PVHD303 disturbed microtubule formation at the centrosomes and inhibited the growth of tumors dose-dependently in the HCT116 human colon cancer xenograft model in vivo. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Product Details of 89466-08-0)
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Product Details of 89466-08-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts