Application of 3-(Aminomethyl)benzyl Alcohol

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 34231-22-6, name is 3-(Aminomethyl)benzyl Alcohol. A new synthetic method of this compound is introduced below., Quality Control of 3-(Aminomethyl)benzyl Alcohol

Step 3 Preparation of (frans)-methyl 4-((5-(2-((3-(hvdroxymethyl)benzyl)carbamoyl)-6-methylpyriotadiotan-4- vO-2H-tetrazol-2-yl)methyl)cvclohexanecarboxvlate(3-(Amiotanomethyl)phenyl)methanol (prepared as described in step 1 of the synthesis of lambda/-(3- (hydroxymethyl)benzyl)-6-methyl-4-(2-(((frans)-4-(methylsulfonamido)cyclohexyl)methyl)-2H-tetrazol- 5-yl)piotacoliotanamiotade, Example 183) (1 15 mg, 0 838 mmol) was added to a solution of methyl 4-(2- (((trans )-4-(methoxycarbonyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpiotacoliotanate (75 mg, 0 201 mmol) in lambda/,lambda/-diotamethylformamiotade (6 mL) and the mixture was heated at 60 0C for 3 days The reaction mixture was purified by reverse-phase preparative HPLC to afford the title compound as a solid (50 mg, 65%) LC/MS (0%-25% CH3CN/H2O, 5 mm ) 3 010 mm , m/z 479 (M+H) 1H NMR (400 MHz, methanol-^) delta ppm 1 10 – 1 24 (m, 2 H), 1 34 – 1 49 (m, 2 H), 1 74 (dd, ,7=13 7, 3 0 Hz, 2 H), 1 99 (dd, .7=13 8, 3 1 Hz, 2 H), 2 03 – 2 16 (m, 1 H), 2 23 – 2 35 (m, 1 H), 2 65 – 2 71 (m, 3 H), 3 62 (s, 3 H), 3 96 (s, 1 H), 4 62 (d, J=7 0 Hz, 2 H), 4 74 (s, 2 H), 7 77 (d, J=8 1 Hz, 1 H), 8 03 (dd, .7=8 2, 1 5 Hz, 1 H), 8 09 (d, J= 1 1 Hz, 1 H), 8 54 (s, 1 H), 8 72 (d, J= 1 6 Hz, 1 H)

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Reference:
Patent; PFIZER INC.; WO2009/16498; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts