The author of 《Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH-sensitive polymeric micelle》 were Shan, Xiaotian; Mao, Jing; Long, Miaomiao; Ahmed, Kamel S.; Sun, Changling; Qiu, Lipeng; Chen, Jinghua. And the article was published in Journal of Applied Polymer Science in 2019. Electric Literature of C3H9NO2 The author mentioned the following in the article:
Polyethylene glycol (PEG) and pH-sensitive polymers have been widely utilized in anticancer drug delivery systems due to their characteristics of prolonging circulation time and tumor-responsive drug release. However, the effect of PEG mol. weight on the delivery of anticancer drug-encapsulating pH-sensitive polymer micelles has been poorly studied. Therefore, a simple method was used to prepare pH-sensitive doxorubicin (DOX)-loaded micelles (DOX/POD) based on polyethylene glycol-2-(octadecyloxy)-1, 3-dioxan-5-amine (POD) polymers, and the influence of PEG mol. weights (1 K, 2 K, and 5 K) on in vitro drug release and antitumor effect was further studied. Interestingly, as the mol. weight increased, the release amount of DOX was augmented. While the cytotoxicity and cellular uptake were increased, the mol. weight was decreased. It is reasonable to speculate that the high mol. weight of PEG may promote the dissolution rate of DOX, and their micelles with uncompact structure are being prone to disassembly in an acid environment. However, the low mol. weight of PEG may contribute to the formation of compact POD micelles, which make it easier to be uptaken by tumor cells resulting in the enhanced antitumor effect. Taken together, the results indicate that pH-sensitive POD micelles with low mol. weight can achieve the efficient delivery of drugs, and PEG mol. weight in pH-sensitive nanocarriers may influence the antitumor effect. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47854. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Electric Literature of C3H9NO2
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