《Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents》 was published in Bioorganic Chemistry in 2020. These research results belong to Djuidje, Ernestine Nicaise; Sciabica, Sabrina; Buzzi, Raissa; Dissette, Valeria; Balzarini, Jan; Liekens, Sandra; Serra, Elena; Andreotti, Elisa; Manfredini, Stefano; Vertuani, Silvia; Baldisserotto, Anna. Recommanded Product: 3,5-Dihydroxybenzaldehyde The article mentions the following:
Oxidative stress is the product or etiol. of various multifactorial diseases; on the other hand, the development of multifunctional compounds is a recognized strategy for the control of complex diseases. A series of benzothiazole derivatives I (R = H, COOH, SO2NH2; R1 = Ph, 2-hydroxyphenyl, 3,4-dihydroxyphenyl, etc.) was synthesized and evaluated for their multifunctional effectiveness as antioxidant, sunscreen (filter), antifungal and antiproliferative agents. Compounds were easily synthesized via condensation reaction between 2-aminothiophenol and different benzaldehydes R1CHO. SAR study, particularly in position 2 and 6 of benzothiazoles, led to the identification of I (R = H, R1 = 2,5-dihydroxyphenyl (A); R = H, R1 = 2,4,5-trihydroxyphenyl) as very interesting potential compounds for the design of multifunctional drugs. In particular, compound (A) is the best blocker of hERG potassium channels expressed in HEK 293 cells exhibiting 60.32% inhibition with IC50 = 4.79μM. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 3,5-Dihydroxybenzaldehyde)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Recommanded Product: 3,5-Dihydroxybenzaldehyde
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