Wang, Yuechun; Wang, Yuqin; Shen, Jiabing; Chen, Xiang published their research in Latin American Journal of Pharmacy in 2021. The article was titled 《Protective effect of azaindole on cerebral hemorrhage in rat model through down-regulation of TGF-β mediated ERK pathway》.Product Details of 7748-36-9 The article contains the following contents:
The present study investigated azaindole as therapeutic agent for treatment of cerebral hemorrhage in the rat model. Azaindole treatment in dose dependent manner enhanced viability of neurons and decreased escape latency in cerebral hemorrhage rats compared to the untreated group. Moreover, infarct volume showed a significant (p < 0.05) decrease in cerebral hemorrhage rats on treatment with azaindole in 1.0 to 1.75 mg/kg dosage range. Azaindole treatment of cerebral hemorrhage rats significantly (p < 0.05) decreased CWC, improved BBB and increased proportion of Iba1 and MPO +ive cells in neuronal cultures. Treatment with azaindole prevented induction of neuronal apoptosis, promoted Bcl2 and Bclxl proteins and suppressed Bad and Bax protein protein expression. Addnl., Azaindole elevated TGF-β and ERK protein expression in cerebral hemorrhage rats. Thus, azaindole promoted viability of neurons and decreased infarct volume in cerebral hemorrhage rats through TGF-β and ERK/p-ERK pathway up-regulation. Therefore, azaindole inhibits neuronal damage and may be developed for ischemic reperfusion mediated cerebral hemorrhage treatment. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9
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