Application of 109-83-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 109-83-1 as follows.
Synthesis of the Acid Unit AC-07: 2-[2-[[(4-Methoxy-2,3,6-trimethyl-phenyl)sulfonyl]-methyl-amino]-ethoxy]-acetic acid (AC-07) Stage-1: 2-Methylaminoethanol 1 (1 eq. 79.9 mmol) was dissolved in 500 ml of methylene chloride, and triethylamine (1.2 eq., 95.9 mmol) and the sulfonyl chloride 2 (1.2 eq., 95.9 mmol), dissolved in 60 ml of methylene chloride, were then added in succession. The mixture was stirred at room temperature for 4 h (TLC control). H2O (100 ml) and sat. NaHCO3 solution (100 ml) were then added to the reaction mixture. After separation of the phases, the aqueous phase was extracted 3* with methylene chloride (250 ml). The combined organic phases were dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography (silica, diethyl ether/hexane 8:2?9:1) to obtain the alcohol 3 (66.3 mmol, 83% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-83-1, its application will become more common.
Reference:
Patent; Gruenenthal GmbH; US2009/264400; (2009); A1;,
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