In 2022,Govindaraju, Santhosh; Daniel, Nobi Kunnathu; Tabassum, Sumaiya published an article in Materials Today: Proceedings. The title of the article was 《Sulfamic acid catalyzed grinding: A facile one-pot approach for the synthesis of polysubstituted pyrazoles under green conditions》.Application In Synthesis of 3-Hydroxybenzaldehyde The author mentioned the following in the article:
A competent, rapid and simple grinding procedure for the synthesis of pharmacol. relevant polysubstituted pyrazoles catalyzed by sulfamic acid was reported via multicomponent reaction of substituted benzaldehydes, 4-nitrophenylacetonitrile, hydrazine hydrate, Et acetoacetate under solvent-free reaction conditions. In this reported protocol, four different reactants featuring diverse functional groups were assembled in one pot, enabling the synthesis of more diverse mol. structures in a facile manner. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application In Synthesis of 3-Hydroxybenzaldehyde
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts