In 2022,Tian, Jun; Yu, Shanshan; Guo, Hongyu; Zhu, Maoshuai; Lu, Kai; Jiang, Yixuan; Yang, Jiaqiao; Yu, Xiaoqi; Pu, Lin published an article in European Journal of Organic Chemistry. The title of the article was 《Enantioselective Fluorescent Recognition of β-Amino Alcohols by Stereoselective Cyclization》.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:
2,2′-Diformyl-1,1′-binaphthyl is found to exhibit highly enantioselective fluorescence enhancement in the presence of various β-amino alcs. and base. It provides a new method to determine the enantiomeric composition of those substrates and has potential for high throughput anal. Based on detailed spectroscopic analyses, it is proposed that a stereoselective cyclization of a β-amino alc. with the probe should occur to form a rigid macrocyclic intermediate, contributing to the greatly enhanced fluorescence. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts