Recommanded Product: 6381-59-5In 2020 ,《Synthesis and Biological Evaluation of Pyrroloindolines as Positive Allosteric Modulators of the α1β2γ2 GABAA Receptor》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Blom, Annet E. M.; Su, Justin Y.; Repka, Lindsay M.; Reisman, Sarah E.; Dougherty, Dennis A.. The article conveys some information:
Here, the synthesis and functional evaluation of a novel series of pyrroloin-dolines, e.g., I that displayed significant modulation of the γ-aminobutyric acid type A (GABAA) receptor, acting as pos. allosteric modulators (PAMs) was described. It was found that halogen incorporation at the C5 position greatly increased the PAM potency relative to the parent ligand, while substitutions at other positions generally decreased potency. Mutagenesis studies suggested that the binding site lies at the top of the transmembrane domain. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Recommanded Product: 6381-59-5)
Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Recommanded Product: 6381-59-5 As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.
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