Recommanded Product: 26153-38-8In 2019 ,《Synthesis, anticancer activity and molecular docking studies of some novel quinoline hydrazide derivatives of substituted benzaldehydes》 appeared in Rasayan Journal of Chemistry. The author of the article were Gayam, Venkatareddy; Ravi, Subban; Ravikumar, G. M. V. N. A. R.; Thangamani, Arumugam. The article conveys some information:
A novel series of quinoline hydrazide bridged derivatives were synthesized by a multistep reaction from vanillic acid. The reactions involved esterification, O-alkylation, nitration, reduction, cyclization, to get 7-(3-hloropropoxy)-4-hydroxy-6-methoxyquinoline-3-carbonitrile 5 which further reacted with Et bromoacetate to yield the corresponding ester 6. Compound 6 react with hydrazine hydrate to afford the hydrazide 7, which then reacted with substituted benzaldehydes to afford the corresponding quinoline-hydrazides 8 – 19. The synthesized compounds were characterized by IR, NMR and MS data. Compounds 7-19 were tested for their cytotoxic activity by Trypan blue, MTT and LDH assays. All the tested compounds showed cytotoxic activity and the results are comparable with the standard compound bosutinib. Compound 12 showed an IC50 value of 26.93 ± 2.8 and 28.92 ± 1.6μg/mL by MTT and trypan blue assay resp. Structure activity relationship was discussed among the compounds 7-19. Mol. docking studies were carried out for all the compounds 7-19 against BCR-ABL T315I protein. Compound 12 showed very good interactions with the protein like any other tyrosine kinase inhibitors. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 26153-38-8)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Recommanded Product: 26153-38-8
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