《Synthesis, Biological Evaluation, and Binding Mode of Novel 1-[2-(Diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles Targeted at the HIV-1 Reverse Transcriptase》 was written by Silvestri, Romano; Artico, Marino; De Martino, Gabriella; Ragno, Rino; Massa, Silvio; Loddo, Roberta; Murgioni, Chiara; Loi, Anna Giulia; La Colla, Paolo; Pani, Alessandra. Quality Control of (3-Chlorophenyl)(phenyl)methanol And the article was included in Journal of Medicinal Chemistry on April 11 ,2002. The article conveys some information:
A novel series of 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazole (DAMNI) analogs were synthesized and tested in cell-based assays and in enzyme assays against HIV-1 recombinant reverse transcriptase (RT). Preparation of the new derivatives was performed by reacting the appropriate benzhydrols or the corresponding bromides with 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole or the 3-hydroxypropyl homolog. Several compounds showed anti-HIV-1 activity in the submicromolar range. Structure-activity relationship studies suggested that meta substitution at one Ph ring of the diarylmethane moiety strongly influences the antiviral activity. 3,5-Disubstitution at the same Ph ring led to less potent derivatives Mol. modeling and docking studies within the RT non-nucleoside binding site confirmed that DAMNIs, similar to other NNRTIs such as TNK-651 and delavirdine (BHAP U90152), assume a butterfly-like conformation that appears to be halfway between that of classical NNRTIs, such as nevirapine, HEPT, TBZ, TIBO, and DABOs, and the conformation of BHAPs. In particular, the diphenylmethane moiety mimics the wings whereas the 1-(2-methyl-5-nitroimidazolyl)ethane portion resembles the BHAP 5-methanesulfonamidoindole-2-carbonylpiperazine portion. In the experiment, the researchers used many compounds, for example, (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Quality Control of (3-Chlorophenyl)(phenyl)methanol)
(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Quality Control of (3-Chlorophenyl)(phenyl)methanol
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