COA of Formula: C13H19Br2ClN2OOn May 31, 2021, Pobudkowska, Aneta; Sliwinska, Agnieszka; Nosol, Kamil published an article in Journal of Solution Chemistry. The article was 《Physicochemical Properties and Solubility of Hydrochloride Mucolytic Agents》. The article mentions the following:
Two widely used active pharmaceutical ingredients (API), ambroxol hydrochloride (AMB·HCl) and bromhexine hydrochloride (BMH·HCl), belong to the expectorant and mucokinetic group of drugs. Their applications are found in the treatment of the upper respiratory tract and bronchopulmonary diseases. The compounds have similar chem. structures, but are different enough to distinguish their physicochem. properties. To understand better the bioavailability of the drugs a series of experiments was performed to establish significant parameters. With differential scanning calorimetry (DSC) the temperature and the enthalpy of fusion were determined with no observed polymorphic transformations. The phase diagrams for binary systems {active agent (1) + solvent (2)} were determined with three solvents: 1-octanol, water and ethanol, to describe phase equilibrium by correlation with the local composition models: Wilson, UNIQUAC and NRTL. Finally, the Bates-Schwarzenbach method was used to establish the ionization constants of AMB·HCl and BMH·HCl at two temperatures: room temperature 298.2 K and human body temperature 310.2 K. Our study can give an insight into further drug delivery system design and help to create more effective drug application forms. The results came from multiple reactions, including the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4COA of Formula: C13H19Br2ClN2O)
trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.COA of Formula: C13H19Br2ClN2O It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.
Referemce:
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Alcohols – Chemistry LibreTexts