Sitte, Nikolai A.; Ghiringhelli, Francesca; Shevchenko, Grigory A.; Rominger, Frank; Hashmi, A. Stephen K.; Schaub, Thomas published an article in Advanced Synthesis & Catalysis. The title of the article was 《Copper-Catalysed Synthesis of Propargyl Alcohol and Derivatives from Acetylene and other Terminal Alkynes》.Computed Properties of C8H7NO The author mentioned the following in the article:
A copper(I)/phosphine system that homogeneously catalyzed the alkynylation of formaldehyde with acetylene or terminal alkynes to afford propargyl alc. and derivatives RCCCH2OH [R = Ph, 4-MeOC6H4, 3-HOC6H4, etc.] was reported. Using acetylene at atm. pressure, the catalyst consisting of <1 mol% copper(I) phenylacetylide and a trialkyl bisphosphine ligand showed a high selectivity toward the formation of propargyl alcs. rather than 1,4-butynediol, which was not reported for common heterogeneous copper acetylide catalysts. The biphasic water/toluene reaction mixture allowed the separation of targeted products with the aqueous layer and catalyst recycling via the organic layer. In addition to this study using 3-(4-Pyridyl)-2-propyn-1-ol, there are many other studies that have used 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Computed Properties of C8H7NO) was used in this study.
3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Computed Properties of C8H7NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts