The author of 《Efficient labeling of organic molecules using 13C elemental carbon: Universal access to 13C2-labeled synthetic building blocks, polymers and pharmaceuticals》 were Ledovskaya, Maria S.; Voronin, Vladimir V.; Rodygin, Konstantin S.; Ananikov, Valentine P.. And the article was published in Organic Chemistry Frontiers in 2020. COA of Formula: C12H20O6 The author mentioned the following in the article:
Among different types of labeling, 13C-labeled compounds are the most demanding in organic chem., life sciences and materials design. However, 13C-labeled organic mols. are very difficult to employ in practice due to extreme cost. The rather narrow range of labeled organic starting materials and the absence of universal synthetic building units further complicate the problem and make utilization of 13C-labeled mols. hardly possible in many cases. Here, we report a versatile approach for 13C2-labeling of organic mols. starting with 13C elemental carbon: 13C carbon is applied for the synthesis of calcium carbide (Ca13C2), which is subsequently used to generate acetylene – a universal 13C2 unit for atom-economic organic transformations. Syntheses of labeled alkynes, O,S,N-functionalized vinyl derivatives, polymers and pharmaceutical substances were demonstrated. Elemental 13C carbon, as the chem. most simple source for 13C2-labeling, was successfully combined with universal synthetic applicability of alkynes. In the experimental materials used by the author, we found ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6COA of Formula: C12H20O6)
((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II). And it is used as chiral auxiliaries in Michael and Aldol addition reactions.COA of Formula: C12H20O6
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