Wild, Christopher T.’s team published research in Journal of Medicinal Chemistry in 2019 | CAS: 534-03-2

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Synthetic Route of C3H9NO2

In 2019,Journal of Medicinal Chemistry included an article by Wild, Christopher T.; Miszkiel, Joanna M.; Wold, Eric A.; Soto, Claudia A.; Ding, Chunyong; Hartley, Rachel M.; White, Mark A.; Anastasio, Noelle C.; Cunningham, Kathryn A.; Zhou, Jia. Synthetic Route of C3H9NO2. The article was titled 《Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor》. The information in the text is summarized as follows:

Cis-alkylpiperidinecarboxamides such as I were prepared as pos. allosteric modulators of the 5-HT2c receptor for potential use in the prevention of cocaine addiction relapse. I potentiated 5-HT-evoked intracellular calcium release in cells stably expressing the human 5-HT2c receptor but not cells expressing human 5-HT2a receptors. Mol. docking calculations of I at the 5-HT2c receptor identified a topog. distinct allosteric site. The pharmacokinetics of I upon i.v. administration, its toxicity, and its selectivity for the 5-HT2c receptor over a variety of other competing receptors was determined I modulated 5-HT2c receptor-mediated spontaneous ambulation, partially substituted for the training dose of the 5-HT2c receptor agonist WAY163909, synergized with a low dose of WAY163909 to substitute fully for the stimulus effects of WAY163909, and attenuated relapse vulnerability as assessed in a rodent self-administration model, indicating its therapeutic promise for cocaine use disorder. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Synthetic Route of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Synthetic Route of C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts