In 2019,European Journal of Medicinal Chemistry included an article by Feng, Yue; Xie, Xiao-Yang; Yang, Yi-Qiu; Sun, Yu-Tong; Ma, Wen-Hui; Zhou, Peng-Jun; Li, Zi-Yao; Liu, Hui-Qiang; Wang, Yi-Fei; Huang, Yun-Sheng. Electric Literature of C6H13NO. The article was titled 《Synthesis and evaluation of pyrimidoindole analogs in umbilical cord blood ex-vivo expansion》. The information in the text is summarized as follows:
The synthesis of pyrimidoindole analogs I [R = dimethylamino, 3-chloro-4-fluoroanilino, 3,4-dimethoxyphenthylamino, etc.] and II [R1 = anilino, morpholino, indole-3-ethylamino, etc.] and identified 6 compounds to be potent in promoting HSC ex vivo expansion. In particular, analog I [R = 2-(6,7-dimethoxy-1,2,3,4-trtrahydroisoquinolino)ethylamino (III)] was found to be the most effective in stimulating ex-vivo expansion of UCB CD34+ cells and CD34+CD38- cells. Initial data indicated that compound III promoted the absolute number of long term HSCs and inhibited their differentiation. UCB HSCs expanded with III retained adequate multi-lineage differentiation capacity. In addition, compound III was not cytotoxic at its test concentrations, suggested that it merits further investigation for potential clin. applications. In the experiment, the researchers used many compounds, for example, trans-4-Aminocyclohexanol(cas: 27489-62-9Electric Literature of C6H13NO)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Electric Literature of C6H13NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts