The origin of a common compound about Methyl 3-hydroxy-2,2-dimethylpropanoate

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14002-80-3, Methyl 3-hydroxy-2,2-dimethylpropanoate.

Reference of 14002-80-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14002-80-3, name is Methyl 3-hydroxy-2,2-dimethylpropanoate, molecular formula is C6H12O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step A: methyl 3 -(5-bromopyridin-2-yloxyV2,2-dimethylpropanoateSodium hydride (60% disp. in oil, 908.0 mg, 22.7 mmol) was added portionwise at RT to a solution of 5-bromo~2-fiuoropyridine (1.16 mL, 11.4 mmol) and methyl 3-hydroxy-2,2- dimethylpropanoate (1.88 mL, 14.8 mmol) in anhydrous THF (33 mL) and dry 1 ,3 -dimethyl – 3,4,5,6-tetraliydro-2(lH)-pyrimidinone (5.0 mL) under argon. After 2 h of stirring at RT, the reaction mixture was heated at 50 C for 10 h and then at 70 C for 3 h. The suspension was cooled to RT and filtered over a thin celite pad. The celite pad was rinsed with Et20 (150 mL). The filtrate was concentrated to a volume of ca. 5 mL, then diluted with Et20 (150 mL), quenched with water (90 mL) and decanted. The aqueous layer was extracted with Et20; the combined organic extract was successively washed with water then brine, dried (MgSC^), filtered and concentrated. Purification by silica gel chromatography (eluant: 0-20%EtOAc hexanes) yielded the title compound as a clear oil. MS = 288, 290 [M+l).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14002-80-3, Methyl 3-hydroxy-2,2-dimethylpropanoate.

Reference:
Patent; MERCK SHARP & DOHME CORP.; TING, Pauline, C.; ASLANIAN, Robert; CAO, Jianhua; KIM, David; ZORN, Nicolas; WO2012/24179; (2012); A1;,
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