Arcadi, Antonio; Calcaterra, Andrea; Fabrizi, Giancarlo; Fochetti, Andrea; Goggiamani, Antonella; Iazzetti, Antonia; Marrone, Federico; Mazzoccanti, Giulia; Serraiocco, Andrea published the artcile< One-pot synthesis of dihydroquinolones by sequential reactions of o-aminobenzyl alcohol derivatives with Meldrum's acids>, Synthetic Route of 5344-90-1, the main research area is quinolinone dihydro preparation; aminobenzyl alc heterocyclization Meldrum acid.
The functionalized 3,4-dihydroquinolin-2-ones I (R1 = Me, 4-MeOC6H4CH2, 4-BrC6H4CH2, 4-MeSC6H4CH2, 2-furylmethyl; R2 = H, Cl; R3 = H, Me, MeO; R4 = H, CF3) have been assembled in good to high yields through the sequential reaction of readily available N-Ts-o-aminobenzyl alcs. II with 5-R1-substituted Meldrum’s acids under mild basic conditions. Highly diastereoselective synthesis of trans-3-R1-4-phenyl-1-tosyl-3,4-dihydroquinolin-2(1H)-ones was accomplished from 2-(tosylamino)-α-phenylbenzenemethanol under the same reaction conditions. Regarding the reaction mechanism, the formation of dihydroquinolones proceeds through the in situ generation of aza-o-QMs followed by conjugate addition of enolate/cyclization/elimination of acetone and CO2.
Organic & Biomolecular Chemistry published new progress about Amino alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Synthetic Route of 5344-90-1.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts