Xu, Pei; Wang, Xing-Yu; Wang, Zhijuan; Zhao, Jinjin; Cao, Xu-Dong; Xiong, Xiao-Chun; Yuan, Yu-Chao; Zhu, Songlei; Guo, Dong; Zhu, Xu published the artcile< Defluorinative Alkylation of Trifluoromethyl Benzimidazoles Enabled by Spin-Center Shift: a Synergistic Photocatalysis/Thiol Catalysis Process with CO2·->, Electric Literature of 627-27-0, the main research area is difluoromethyl benzimidazole preparation; trifluoromethyl benzimidazole unactivated alkene reductive defluoroalkylation iridium.
Authors describe a catalytic strategy for direct single C(sp3)-F bond alkylation of trifluoromethylbenzimidazoles under a photoinduced thiol-catalysis process. The CO2 radical anion (CO2·-) was proven the efficient single electron reductant to realize such transformation. The spin-center shift of the generated radical anion intermediate is the key step to realize the C-F bond activation in mild conditions with high efficiency.
Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts