Wang, Hanhan; Hu, Mengjun; Wang, Xiao-Na; Chang, Junbiao published the artcile< Metal-free hydroalkoxylation of ynesulfonamides with alcohols>, COA of Formula: C4H8O, the main research area is alkoxy enamide preparation regioselective diastereoselective; ynesulfonamide alc hydroalkoxylation triflic acid catalyst.
Efforts for developing a convenient and expeditious method for synthesizing alkoxy-substituted enamides RS(O)2N(R1)C(OR3)=CHR2 (R = Me, 4-methylphenyl, 4-nitrophenyl, 4-chlorophenyl, 4-methoxyyphenyl; R1 = Me, n-Bu, Bn, allyl; R2 = Me, Ph, thiophen-2-yl, etc.; R3 = Et, Bn, cyclopentyl, etc.) via nucleophilic addition of alcs. R3OH to ynesulfonamides RS(O)2N(R1)CCR2 were described. This sequence is completely regioselective and highly stereoselective, and leads to the hydroalkoxylation products in high yields under mild reaction conditions.
Organic & Biomolecular Chemistry published new progress about Alkoxylation catalysts, reductive (regioselective). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts