Kwon, Yu-Jin; Jang, Su-Nyeong; Liu, Kwang-Hyeon; Jung, Dong-Hyuk published the artcile< Effect of Korean red ginseng on cholesterol metabolites in postmenopausal women with hypercholesterolemia: a pilot randomized controlled trial>, SDS of cas: 434-16-2, the main research area is Korean red ginseng cholesterol postmenopause hypercholesterolemia; Korean red ginseng; cholesterol metabolism; menopause; sterols; women.
Korean red ginseng (KRG) is known to exert beneficial effects on cardiovascular health. Meanwhile, reduced estrogen at menopause has been shown to have various adverse impacts on cardiovascular risk factors, including blood lipids. The aim of this pilot study was to investigate the effect of KRG on cholesterol metabolites, which are surrogate markers of cholesterol absorption and biosynthesis, in postmenopausal women with hypercholesterolemia. The present study is an exploratory study which used data from a 4-wk, double-blinded, placebo-controlled clin. pilot study in 68 postmenopausal women with hypercholesterolemia. Patients received KRG (2 g) or placebo (2 g) once daily. The primary endpoints were changes in the levels of nine sterols. Serum sterols were analyzed using liquid chromatog.-mass spectrometry (LC-MS)/MS anal. Among the sterols, reduction in cholesterol level were significantly larger in the KRG group than in the placebo group (the changes: -148.3 ± 261.1 nmol/mL in the ginseng group vs. -23.0 ± 220.5 nmol/mL in the placebo group, p = 0.039). Addnl., changes in 7-hydroxycholesterol (7-OHC) were significantly larger in the KRG group than in the placebo group (the changes: -0.05 ± 0.09 nmol/mL in the ginseng group vs. -0.002 ± 0.1 nmol/mL in the placebo group, p = 0.047). Oxysterols, cholesterol derivates, have been known to play a role in chronic inflammation diseases such as cardiovascular diseases. KRG improves sterol metabolism by decreasing cholesterol and 7-OHC levels in postmenopausal women with hypercholesterolemia.
Nutrients published new progress about Bicycling. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, SDS of cas: 434-16-2.
Referemce:
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Alcohols – Chemistry LibreTexts