Donthireddy, S. N. R.; Pandey, Vipin K.; Rit, Arnab published the artcile< [(PPh3)2NiCl2]-Catalyzed C-N Bond Formation Reaction via Borrowing Hydrogen Strategy: Access to Diverse Secondary Amines and Quinolines>, Category: alcohols-buliding-blocks, the main research area is aryl amine methanol nickel catalyst alkylation reaction; arylmethylamine preparation; aminobenzyl alc ethanone nickel catalyst dehydrogenation heterocyclization; quinoline preparation.
Com. available [(PPh3)2NiCl2] was found to be an efficient catalyst for the mono-N-alkylation of (hetero)aromatic amines, employing alcs. to deliver diverse secondary amines, including the drug intermediates chloropyramine and mepyramine in excellent yields (up to 97%) via the borrowing hydrogen strategy. This method shows a superior activity (TON up to 10000) with a broad substrate scope at a low catalyst loading of 1 mol % and a short reaction time. Further, this strategy was also successful in accessing various quinoline derivatives following the acceptorless dehydrogenation pathway.
Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts