Qu, Xianfeng; Chen, Xiao; Shi, Qingqing; Wang, Xiaofei; Wang, Dongguo; Yang, Li published the artcile< Resveratrol alleviates ischemia/reperfusion injury of diabetic myocardium via inducing autophagy>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol beclin1 interleukin6 ischemia reperfusion injury diabetic myocardium; diabetes; ischemia/reperfusion injury; resveratrol autophagy.
The rising incidence and complications of diabetes constitutes a major public health issue. The mortality rate of diabetes-induced myocardial ischemia/reperfusion (I/R) injury is significantly elevated. Resveratrol (RSV) is a naturally occurring polyphenol considered to be a potent cardioprotective compound The aim of the present study was to explore the function and mol. mechanism of RSV on diabetes-induced myocardial I/R injury. Left anterior descending coronary artery ligation was performed to stimulate myocardial I/R injury in streptozotocin-induced diabetic rats. Heart elec. activity was monitored through an ECG to confirm successful models. The myocardial infarct volume was detected via 2,3,5-triphenyltetrazolium chloride staining. Western blotting was employed to examine the levels of autophagy markers. It was found that the injection of RSV mitigated the ischemia- or I/R injury-induced myocardial damage on hemodynamic function and infarct size, but the autophagy inhibitor 3-methyladenine significantly blocked the function of RSV. Furthermore, the application of RSV significantly enhanced the expression of Beclin-1 and LC-3II but inhibited the serum levels of tumor necrosis factor-α and interleukin-6. These findings revealed an alleviating effect of RSV on diabetes-induced myocardial I/R injury and provided new evidence for the successful application of RSV on the diabetic myocardium.
Experimental and Therapeutic Medicine published new progress about Autophagy. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts