An, Taeyang; Lee, Yan published the artcile< Nucleophilic Substitution at the Guanidine Carbon Center via Guanidine Cyclic Diimide Activation>, Category: alcohols-buliding-blocks, the main research area is guanidine carbon center preparation; amine guanidine cyclic diimide nucleophilic substitution; alc guanidine cyclic diimide nucleophilic substitution.
Despite the electron-deficient nature of the guanidine carbon centers R1NHC(NH2)=NH+R2Cl- (R1 = n-Bu, Ph, cyclohexyl, etc.; R2 = Ph, naphthalen-1-yl, 2H-1,3-benzodioxol-5-yl, etc.) and R1NHC(O)NHC(O)(CH2)2C(O)OR2, nucleophilic reactions at these sites have been underdeveloped due to the resonance stabilization of the guanidine group. A guanidine C-N bond substitution strategy entailing the formation of guanidine cyclic diimide (GCDI) structures I, which effectively destabilize the resonance structure of the guanidine group was proposed. In the presence of acid additives, the guanidine carbon center of GCDIs I undergoes nucleophilic substitution reactions with various amines R2NH2 and alcs. R2OH.
Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts