Nguyen, Thao T.; Nguyen, Khang X.; Pham, Phuc H.; Ly, Duc; Nguyen, Duyen K.; Nguyen, Khoa D.; Nguyen, Tung T.; Phan, Nam T. S. published the artcile< Copper-catalyzed synthesis of pyrido-fused quinazolinones from 2-aminoarylmethanols and isoquinolines or tetrahydroisoquinolines>, Computed Properties of 5344-90-1, the main research area is aminoarylmethanol isoquinoline copper catalyst amination annulation cascade reacation; isoquinolino quinazolinone preparation; tetrahydroisoquinoline aminoarylmethanol copper catalyst amination annulation cascade reacation; dihydroisoquinolino quinazolinone preparation.
Pyrido-fused quinazolinones were synthesized via copper-catalyzed cascade C(sp2)-H amination and annulation of 2-aminoarylmethanols with isoquinolines or pyridines. The transformation proceeded readily in the presence of a com. available CuCl2 catalyst with mol. oxygen as a green oxidant. Moreover, the dehydrogenative cross-coupling of 2-aminoarylmethanols with tetrahydroisoquinolines were explored, in which CuBr exhibited higher catalytic activity than CuCl2. Broad substrate scope with good tolerance of functionalities were observed under the optimized reaction conditions. The bioactive naturally occurring alkaloid rutaecarpine was obtained by this strategy. The remarkable feature of this protocol was that complicated heterocyclic structures were readily achieved in a single synthetic step from easily accessible reactants and catalysts. The pathway to pyrido-fused quinazolinones would be complementary to existing protocols.
Organic & Biomolecular Chemistry published new progress about Amination. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.
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