Zhu, Man; Chen, Yao; Zhao, Ninghui; Bai, Hua; Zhang, Keqin; Huang, Xiaowei published the artcile< Multiple olfactory pathways contribute to the lure process of Caenorhabditis elegans by pathogenic bacteria>, SDS of cas: 104-76-7, the main research area is Caenorhabditis multiple olfactory pathway lure process pathogenic bacteria; B. nematocida B16; Caenorhabditis elegans; attractant; chemotaxis; host; olfactory signaling pathway; pathogenic bacteria.
Abstract: Chemosensation is indispensable for the survival of Caenorhabditis elegans to discriminate food and pathogenic bacteria in their living environment. Food-like odors emitted by the pathogen Bacillus nematocida B16 for trapping its hosts and an olfactory signaling pathway responsible to sense the attractant 2-heptanone were identified in our previous study. Here, we further explore how the worms recognize the attractive mols. indole and 2-Et hexanol, which have different chem. properties and modest nematode-luring ability. We show that the chemotaxis toward indole and 2-Et hexanol requires the G protein-coupled receptors encoded by str-193 on AWC and str-7 on AWA. In a further genetic screen for downstream effectors in olfactory signaling cascades, the Gα subunit GSA-1, guanylyl cyclase ODR-1 and DAF-11 and the cGMP-gated channel TAX-2/TAX-4 were found to be necessary for indole sensation, whereas the TRPV channels OSM-9/OCR-2 and the PLC pathway activated by GPA-6 are responsible for the detection of 2-Et hexanol. Altogether, our current work further clarifies the distinct olfactory signaling pathways through which C. elegans senses different chems. and is lured by B. nematocida B16, improving our comprehensive understanding of the mechanisms by which bacterial pathogens effectively infect their hosts.
Science China: Life Sciences published new progress about Bacillus nematocida (B16). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, SDS of cas: 104-76-7.
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