Jeandet, Philippe; Sobarzo-Sanchez, Eduardo; Silva, Ana Sanches; Clement, Christophe; Nabavi, Seyed Fazel; Battino, Maurizio; Rasekhian, Mahsa; Belwal, Tarun; Habtemariam, Solomon; Koffas, Mattheos; Nabavi, Seyed Mohammad published the artcile< Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives>, Application of C14H12O3, the main research area is Biocatalysis; Enzymatic transformation; Green chemistry; Laccases; Peroxidases; Resveratrol; Resveratrol glucosides; Resveratrol oligomers; Stilbenes; Whole cell biocatalysis.
Resveratrol and the biosynthetically related stilbenes are plant secondary metabolites with diverse pharmacol. effects. The versatile functions of these compounds in plant defense mechanisms as phytoalexins on one hand, and in human health as potential pharmaceutical agents on the other, have attracted lots of interest in recent years to understand their biosynthetic pathways and their biol. properties. Because of difficulties in obtaining resveratrol and its glucosylated derivatives as well as oligomeric forms in sufficient amounts for evaluation of their activity by plant sourcing or total synthesis, biotechnol. may provide a competitive approach for the large-scale and low cost production of biol. active stilbenes. Addnl., one major limitation in the use of resveratrol and related aglycon derivatives as therapeutic agents is associated with their inherent poor aqueous solubility and low bioavailability. This article examines approaches for the synthesis of potential pharmacol. resveratrol derivatives in vivo by exploiting whole microorganisms, enzymic and biocatalytic approaches allowing their full utilization for medicine, food and cosmetic applications. These methods also have the advantage of enabling the one-step production of stilbene compounds, compared to the time-consuming and environmentally unfriendly procedures used for their total synthesis or their extraction from plants. Increasing the desired products yield and biol. activity through glucosylation (β-D-glucosides vs. α-D-glucosides) and oligomerization methodologies of resveratrol including green chem. methods in organic solvent-free media are discussed as well.
Biotechnology Advances published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts