Guo, Guifang; Chen, Xiuxing; Cai, Xiuyu; Chen, Yanfeng; Wang, Haohua; Fan, Lei; Bai, Long; Qiu, Huijuan; Zhang, Bei published the artcile< Inflammation-based markers can predict the prognosis of geriatric patients with metastatic colorectal cancer receiving first-line chemotherapy>, Related Products of 1492-18-8, the main research area is colorectal cancer anticancer agent metastasis; C-reactive protein (CRP); Colorectal cancer; carbohydrate antigen 19-9 (CA 19-9); carcinoembryonic antigen (CEA); geriatric patient; inflammation; lactate dehydrogenase (LDH); neutrophil-to-lymphocyte ratio (NLR).
A total of 186 MCRC patients aged =65 years, receiving chemotherapy between Jan. 1, 2004 and Oct. 1, 2015 were identified. Pretreatment levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), LDH, CRP and NLR were measured. Effect of these inflammatory factors on overall survival (OS) and first-line progression-free survival were analyzed. Median PFS and OS were 6.70 mo and 25.62 mo. CEA =85 ng/mL (P=0.010), CA 19-9 =32.97 U/mL (P=0.010), LDH =325 U/L (P=0.015), CRP =11 mg/L (P=0.004) and NLR =2.12 (P=0.045) were associated with poor OS. Furthermore, LDH (P=0.025) was demonstrated as an independent prognostic factor of OS for all patients, so did the combination of CEA with CA 19-9 (P=0.009). When predicting the one, three and five-year survival, combination of CEA with CA 19-9 had higher sensitivity compared with CEA alone or CA 19-9 alone resp. For right-sided colon cancer, CEA (P<0.001) and CA 19-9 (P=0.003) were related with OS and CEA (P=0.002) was the independent prognostic factor. For left-sided colorectal cancer, inflammatory factors related with OS were LDH (P=0.039), CRP (P=0.004) and NLR (P=0.020) and CRP (P=0.040) was the independent prognostic factor. However, no inflammatory factors were contained in multivariate COX regression. CEA, CA 19-9, LDH, CRP and NLR were related with OS in geriatric patients with MCRC. Right-sided and left-sided groups had different independent prognostic markers, CEA and CRP resp. Translational Cancer Research published new progress about Biomarkers. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Related Products of 1492-18-8.
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