Shi, Yang; Ye, Yun-Fang; Zhang, Bi-Wei; Liu, Yong; Wang, Jun-Hui published the artcile< Purification, structural characterization and immunostimulatory activity of polysaccharides from Umbilicaria esculenta>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Umbilicaria esculenta polysaccharide immunostimulatory activity; Immunostimulatory activity; Polysaccharides of Umbilicaria esculenta; Structural characterization.
In this study, an active component UP1-1 was isolated from Chinese Huangshan Umbilicaria esculenta via hot water extraction and purified by anion-exchange and gel-filtration chromatog. UP1-1 mainly composed of galactose, mannose and glucose in a molar ratio of 0.8:1.0:4.6 with an average mol. weight of 281 kDa. Methylation anal. of UP1-1 revealed the major glycosidic bonds comprised 1,6-linked Glcp, 1,4-linked Glcp, t-linked Glcp, 1,3,6-linked Manp, 1,3-linked Galp, t-linked Galp at the ratio of 2.28:0.38:0.32:0.63:0.25:0.29. Structural anal. results revealed that the backbone of UP1-1 consisted of (6)-β-D-Glcp-(1→ ,→6)-β-D-Manp-(1→, → 4)-β-D-Glcp-(1 → residues with side chains of →3)-β-D-Galp-1→, β-D-Galp-1→ and β-D-Glcp-1→ branches located at O-3 position of → 6-β-D-Manp-1→. Immunostimulatory activity tests showed that UP1-1 could promote the phagocytic activity and NO production of RAW 264.7 cells in a dose-dependent manner. UP1-1 could significantly improve the proliferation effect of RAW 264.7 cells at the concentration of 50 μg/mL. Thus, UP1-1 exerted good immunostimulatory activity, suggesting that UP1-1 has a great potential application in pharmacol. industry.
International Journal of Biological Macromolecules published new progress about Anion exchange membranes. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.
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