Alderborn, G.; Lang, P. O.; Sagstrom, A.; Kristensen, A. published the artcile< Compression characteristics of granulated materials. I. Fragmentation propensity and compactibility of some granulations of a high dosage drug>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is granule compactibility fragmentation ethanol binder; azobishydroxybenzoate granule tablet property.
Three granulations of a fairly water-soluble high-dosage drug, di-Na 3,3′-azobis(6-hydroxybenzoate), were produced by intensive mixing with poly(vinylpyrrolidone), and dissolved in 3 liquids with different amounts of EtOH and water, as binder. The granulations were mixed with dry binders or with a lubricant and granulations and mixtures were compressed at 30 MPa and the tablet strength was measured. The tablet strength increased with increasing amount of EtOH in the binder solution The increase and decrease in tablet strength due to the addition of dry binder and lubricant, resp., were also dependent on the amount of EtOH in the binder solution and indicated that the degree of fragmentation varied between the granulations. Heckel plots and tablet surface area-compaction pressure profiles confirmed the finding that the degree of fragmentation of the granules increased with increasing amount of EtOH in the binding solution A good correlation between fragmentation propensity of the granulations and tensile strength of the tablets was found.
International Journal of Pharmaceutics published new progress about Pharmaceutical granules. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts