Grinan-Ferre, Christian; Bellver-Sanchis, Aina; Izquierdo, Vanessa; Corpas, Ruben; Roig-Soriano, Joan; Chillon, Miguel; Andres-Lacueva, Cristina; Somogyvari, Milan; Soti, Csaba; Sanfeliu, Coral; Pallas, Merce published the artcile< The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer′s disease pathology: From antioxidant to epigenetic therapy>, Reference of 501-36-0 , the main research area is review cognitive decline alzheimer disease neuroprotective antioxidant epigenetic resveratrol; Antioxidants; Epigenetic; Gut microbiota; Klotho; Neurodegeneration; Resveratrol; Senescence.
A review. While the elderly segment of the population continues growing in importance, neurodegenerative diseases in crease exponentially. Lifestyle factors such as nutrition, exercise, and education, among others, influence ageing progression, throughout life. Notably, the Central Nervous System (CNS) can benefit from nutritional strategies and dietary interventions that prevent signs of senescence, such as cognitive decline or neurodegenerative dis eases such as Alzheimer′s disease and Parkinson′s Disease. The dietary polyphenol Resveratrol (RV) possesses antioxidant and cytoprotective effects, producing neuroprotection in several organisms. The (OS) occurs because of (ROS) accumulation that has been proposed to explain the cause of the ageing. One of the most harmful effects of ROS in the cell is DNA damage. Nevertheless, there is also evidence demonstrating that OS can produce other mol. changes such as mitochondrial dysfunction, inflammation, apoptosis, and epigenetic modifications, among others. Interestingly, the dietary polyphenol RV is a potent antioxidant and possesses pleiotropic actions, exerting its activity through various mol. pathways. In this review, we give a comprehensive overview of the main mechanisms of action of RV in different exptl. models, including clin. trials and discuss how the interconnection of these mol. events could explain the neuroprotective effects induced by RV.
Ageing Research Reviews published new progress about Accelerated aging disorder. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .
Referemce:
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