Itagimatha, N.; Manjunatha, D. H. published an article in Annales Pharmaceutiques Francaises. The title of the article was 《RP-HPLC-UV method development and validation for simultaneous determination of terbutaline sulphate, ambroxol HCl and guaifenesin in pure and dosage forms》.SDS of cas: 23828-92-4 The author mentioned the following in the article:
The objective of the present work was to develop and validate a simple, sensitive, rapid and stable reverse-phase high performance liquid chromatog. (RP-HPLC) method for a combination of Terbutaline sulfate (TSL), Ambroxol hydrochloride (AML) and Guaifenesin (GFN).The combination of these drugs was analyzed by using Shimadzu LC 2010 CHT high performance liquid chromatog. (HPLC). Successful separation was achieved by isocratic elution on a reverse-phase C18 column (sun fire) (250 mm, 4.6 mm, 5μg), using a mobile phase consisting of buffer: acetonitrile in the ratio 80: 20 (buffer – 0.1% volume/volume triethyleamine pH-3.0) followed by 1.0 mL/min flow rate. The wavelength of detection was at 220 nm.The chromatog. retention times were consistent at 3.0, 10.5 and 13.8 min for TSL, AML and GFN resp. For these three compounds, the lower limit of detection was 1.0, 1.25, and 1.5μg/mL and lower limit of quantification was 3.3, 4.1 and 5.0μg/mL resp. The linearity concentrations established for TSL, AML and GFN were 1.0-7.0, 1.5-7.5 and 4.0-14.0μg/mL resp. The correlation coefficients for all the drugs were found to be greater than 0.999. The relative standard deviation of inter- and intra-day were less than 2.0%.This method provides a necessary tool for quantification of the selected drugs for their assay. The proposed method is simple, accurate, reproducible and applied successfully to analyze three compounds in pure as well dosage form. This method provides a necessary tool for quantification of the selected drugs for their assay. After reading the article, we found that the author used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4SDS of cas: 23828-92-4)
trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.SDS of cas: 23828-92-4 Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.
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