The author of 《Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents》 were Ding, Shi; Ji, Jing-Chao; Zhang, Ming-Juan; Yang, Yu-She; Wang, Rui; Zhu, Xing-Long; Wang, Li-Hong; Zhong, Yi; Gao, Le; Lu, Man; Liu, Ju; Chen, Ye. And the article was published in Archiv der Pharmazie (Weinheim, Germany) in 2019. Synthetic Route of C3H6O2 The author mentioned the following in the article:
To gain further knowledge of the structure-activity relationship and druggability of novel oxazolidinone-based UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) inhibitors as Gram-neg. antibacterial agents, compounds containing the hydrophobic tails with different lengths and terminal substitutions were synthesized and their antibacterial activities against standard and clin. isolated Gram-neg. strains were evaluated. We summarized their structure-activity relationships and found that oxazolidinone-based compounds exhibited a narrower antibacterial spectrum compared with threonine-based compounds Furthermore, we parallelly compared the metabolic stabilities of the compounds with the classic threonine scaffold and the novel oxazolidinone scaffold in liver microsomes. The results indicated that the druggability of the oxazolidinone scaffold may be inferior to the classic threonine scaffold in the design of LpxC inhibitors. After reading the article, we found that the author used (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Synthetic Route of C3H6O2)
(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Synthetic Route of C3H6O2
Referemce:
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Alcohols – Chemistry LibreTexts