In 2019,ACS Biomaterials Science & Engineering included an article by Guan, Qinghua; Li, Nan; Shi, Leilei; Yu, Chunyang; Gao, Xihui; Yang, Jiapei; Guo, Yuanyuan; Li, Peiyong; Zhu, Xinyuan. Product Details of 4048-33-3. The article was titled 《Aggregation-Induced Emission Fluorophore-Based Molecular Beacon for Differentiating Tumor and Normal Cells by Detecting the Specific and False-Positive Signals》. The information in the text is summarized as follows:
Accurate and nondestructive detection of tumor-related mRNA in living cells is of great significance for tumor diagnosis. The universal technique for imaging mRNA in living cells is nucleic-acid-based fluorescent probes. However, the majority of developed nucleic-acid-based fluorescent probes were only designed to detect the targeted mRNA but could not avoid the interference arising from nuclease or other biol. matrixes, which results in inevitable false-pos. signals. To overcome this dilemma, a new aggregation-induced emission (AIE) fluorophore and the fluorescence resonance energy transfer (FRET) principle were used to establish a novel AIE fluorophore-based mol. beacon (AIE-MB). The AIE fluorophore tetraphenylethylene-quinoxaline (TPEQ) was designed by incorporating quinoxalinone with one typical AIE active luminogen tetraphenylethene (TPE), which could acquire a wide range of excitation wavelength. On this basis, the AIE-MB was designed by labeling two fluorophores: the TPEQ acceptor and an aggregation-caused quenching (ACQ) fluorophore 7-amino-4-methylcoumarin acid (AMCA) donor. On the basis of these two fluorophores, the AIE-MB could exhibit three states: weak fluorescence at primary stage, blue fluorescence (specific signal) generated by pairing with target mRNA in tumor cells, and both blue and green fluorescence (false-pos. signal) due to the endogenous degradation in normal cells. Obviously, the specific imaging for target mRNA in tumor cells and the false-pos. signal resulting from endogenous degradation in normal cells could be accurately distinguished through the different fluorescence emission. As a result, in contrast to traditional nucleic-acid-based fluorescent probes, the AIE-MB could improve the accuracy of the tumor detection by efficiently differentiating both specific and false-pos. signals, which showed potential application value in tumor diagnosis and biomedical research. The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Product Details of 4048-33-3)
6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Product Details of 4048-33-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts