Alhamed, Samiyah; Alnakhli, Jawzah; Boadi, William; Beni, Ryan published the artcile< Triphenylmethanol conjugates of triptorelin as anti-lipid peroxidation prodrugs>, Electric Literature of 76-84-6, the main research area is triphenylmethanol triptorelin antilipid peroxidation.
Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, unstable mols. that the body produces as a reaction to environmental and other pressures. Free radicals may play a role in heart disease, cancer and other diseases. If the body cannot process and remove free radicals efficiently, oxidative stress can result. This can harm cells and body function. Free radicals are also known as reactive oxygen species (ROS). In this research, Triptorelin (TRP) conjugates of triphenylmethanol derivatives (TPMs) were synthesized to evaluate their in vitro lipid peroxidation potency. Comparative lipid peroxidation assays between TRP-TPMs conjugates and the corresponding TPMs derivatives were measured using thiobarbituric reactive substance (TBARS) in a dose- and time-dependent manner following the Fenton’s pathway. Overall, TBARS decreased between 20% – 30% for the treated samples of synthesized conjugates compared to their resp. control phys. mixtures These data suggest that TRP-TPMs derivatives can be used to improve the biol. activity of TRP.
Open Journal of Medicinal Chemistry published new progress about Lipid peroxidation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Electric Literature of 76-84-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts