Cutolo, Maurizio; Soldano, Stefano; Sulli, Alberto; Smith, Vanessa; Gotelli, Emanuele published the artcile< Influence of seasonal vitamin D changes on clinical manifestations of rheumatoid arthritis and systemic sclerosis>, Category: alcohols-buliding-blocks, the main research area is review vitamin D rheumatoid arthritis systemic sclerosis; circadian rhythms; connective tissue diseases; rheumatoid arthritis; systemic sclerosis; vitamin D.
A review. Vitamin D [1,25(OH)2D-calcitriol] is basically a steroid hormone with pleiotropic biol. effects, and its impact on the regulation of immune system may influence several clin. conditions. Calcidiol (25OHD), as precursor of calcitriol, derives, for the most part (80%), from cutaneous cholesterol (7-dehydrocholesterol) under the action of UV-B (sunlight). Consequently, serum concentrations fluctuate during the year following the circannual rhythm of sun exposition. We will update about the available evidence regarding the complex influence of seasonal vitamin D changes on two different chronic connective tissue diseases, namely rheumatoid arthritis (RA) and systemic sclerosis (SSc). Notably, RA is an emblematic model of autoimmune disease with prevalent joint inflammatory features, while SSc is mainly an autoimmune progressive pro-fibrotic disease. However, in both conditions, low serum concentrations of 25OHD are involved in the pathogenesis of the diseases, and emerging data report their impact on clin. manifestations.
Frontiers in Immunology published new progress about Autoimmune disease. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.
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