Zhao, Jie; Ji, Shufang; Guo, Chenxi; Li, Haijing; Dong, Juncai; Guo, Ping; Wang, Dingsheng; Li, Yadong; Toste, F. Dean published the artcile< A heterogeneous iridium single-atom-site catalyst for highly regioselective carbenoid O-H bond insertion>, Recommanded Product: (R)-Butane-1,3-diol, the main research area is hydroxy ester preparation regioselective; alc diazo ester insertion iridium catalyst.
A strategy for selective carbenoid O-H insertion that exploits an engineered heterogeneous iridium single-atom catalyst, thus providing opportunities for organic transformations by merging material science and catalysis was reported. This catalytic protocol delivers excellent selectivities (up to 99:1) for the functionalization of aliphatic over phenolic O-H bonds R1C6H4CH(R2)C(O)OMe (R1 = H, 4-Br, 3-F, 4-Me; R2 = cyclohexyl, Bn, 2,2,2-trifluoroethyl, 1-methyl-1H-indol-3-yl, etc.), whereas the analogus homogeneous catalyst, Ir(ttp)COCl (ttp = 5,10,15,20-tetra-p-tolylporphyrinato), provided modest preferences. D.-functional-theory calculations suggest that the site-selectivity derives from the lower oxidation state of the iridium metal center in the heterogeneous catalyst and its impact on the absorption energies of the reactants. These results showcase an example of a heterogeneous single-atom catalyst providing superior site-selectivity and provide a complementary strategy to address challenges in catalysis for organic synthesis.
Nature Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Recommanded Product: (R)-Butane-1,3-diol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts