Adding a certain compound to certain chemical reactions, such as: 68120-35-4, (3-Bromo-4-methylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (3-Bromo-4-methylphenyl)methanol, blongs to alcohols-buliding-blocks compound. name: (3-Bromo-4-methylphenyl)methanol
n-BuLi [(18.6 g, 2.5 eq (2.5M soln) was added to a stirred solution of (3-bromo-4- methylphenyl) methanol (5.5 g, 27.4 mmol) in THE (50 mL) at -78 00 and was stirred at same temperature for 30 mm. Then, 002 gas was purged (generated from dry ice)for about 10 mm. The reaction mixture thus obtained was quenched with ammonium chloride and acidified with 1 N HCI, extracted with ethyl acetate, the organic layer was washed with water, brine solution. Then the reaction mixture was dried over anhydrous Na2SO4 and concentrated under reduced pressure and washed with nhexane to obtain the title compound (4.0 g, 87.85%) as an off white solid. LOMS165.0 (M-H) 1H NMR: (ODd3, 300MHz) 6 12.67 (5, 1H), 7.79 (5, 1H), 7.36-7.38 (d,1 H), 7.23-7.25 (d, 1 H), 5.23 (5, 1 H), 4.49 (5, 2H), 2.50 (5, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,68120-35-4, (3-Bromo-4-methylphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MADANAHALLI RANGANATH RAO, Jagannath; GURRAM RANGA, Madhavan; PACHIYAPPAN, Shanmugam; WO2014/202580; (2014); A1;,
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