The author of 《Grignard Reactions in Cyclopentyl Methyl Ether》 were Kobayashi, Shoji; Shibukawa, Keisuke; Miyaguchi, Yuta; Masuyama, Araki. And the article was published in Asian Journal of Organic Chemistry in 2016. Computed Properties of C13H11ClO The author mentioned the following in the article:
A systematic study of Grignard reactions using cyclopentyl Me ether (CPME) as a reaction solvent was studied. Diisobutylaluminum hydride was found to be the most appropriate activator of magnesium and a number of Grignard reagents could be prepared as homogeneous or heterogeneous solutions in CPME. The CPME used in the Grignard reaction was efficiently recycled without affecting the reaction yield of the second experiment GC-MS anal. of the recovered solvent revealed that CPME was stable under the Grignard conditions. Some of the Grignard reagents in CPME were stable for at least several months and therefore these solutions could replace existing com. reagents. Tramadol hydrochloride, an analgesic that is used worldwide, and tamoxifen, an anti-estrogenic drug for estrogen-receptor-pos. breast cancer were synthesized using Grignard reactions in CPME. In the experiment, the researchers used many compounds, for example, (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Computed Properties of C13H11ClO)
(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Computed Properties of C13H11ClO
Referemce:
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