4728-12-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4728-12-5, name is (2,2-Dimethyl-1,3-dioxan-5-yl)methanol, molecular formula is C7H14O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Methyl 5-Hydroxy-1 /-/-indole-2-carboxylate (0.10 g, 0.5 mmol), triphenylphosphine (0.28 g, 1.0 mmol), diethyl azodicarboxylate (0.18 g, 1.0 mmol) and (2,2-dimethyl- 1 ,3-dioxan-5-yl)methanol (0.15 g, 1.0 mmol) were dissolved in CH2CI2 (5 ml.) and the mixture was stirred overnight. The solvent was evaporated. Purification was accomplished by Reverse-Phase HPLC (water/acetonitrile with 0.1percentTFA). The desired fractions were neutralized with saturated NaHCObeta and extracted with EtOAc. The organic extracts were combined dried over Na2SO4, filtered and evaporated to afford the title compound (0.15 g, 90percent) as a tan solid. 1H NMR (400 MHz, DMSO-c/6): delta ppm 1 1.74 (br. s., 1 H), 7.29 (d, 1 H), 7.09 (d, 1 H), 7.01 (d, 1 H), 6.88 (dd, 1 H), 3.92 – 4.01 (m, 4 H), 3.81 (s, 3 H), 3.72 (dd, 2 H), 1.97 – 2.08 (m, 1 H), 1.31 (s, 3 H), 1.28 (s, 3 H). MS: m/z 342.2 (M+23).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4728-12-5, (2,2-Dimethyl-1,3-dioxan-5-yl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/154271; (2008); A1;,
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Alcohols – Chemistry LibreTexts