《Ultrasound-mediated catalyst-free protocol for the synthesis of bis-3-methyl-1-phenyl-1H-pyrazol-5-ols in aqueous ethanol》 was published in Chemical Data Collections in 2020. These research results belong to Shabalala, Nhlanhla Gracious; Kerru, Nagaraju; Maddila, Suresh; van Zyl, Werner E.; Jonnalagadda, Sreekantha B.. Product Details of 100-83-4 The article mentions the following:
An efficient one-pot method for bis-3-methyl-1-phenyl-1H-pyrazol-5-ol derivatives I [R = 2-HO, 2-MeO, 2,4-di-Cl, etc.] under ultrasound irradiation using β-keto ester, phenylhydrazine and benzaldehydes as reactants in aqueous ethanol was reported. Excellent yields (92-99%) were obtained at RT in 5 to 8 min. Products I were characterized by FT-IR, HRMS, 1H and 13C NMR anal. The crystal structure of compound I [R = 2-MeO] was described. Compound I [R = 2-MeO] crystallized in the orthorhombic system with space group Pna21 and along the b-axis of the unit, cell contained four asym. mols. The unit cell parameters were a = 17.2578(2) , b = 17.26256(2) Å, c = 7.76970(10) Å, α = β = γ = 90°, V = 2315.11(5) Å3, Z = 4. The crystal structure was stabilized by an intramol. hydrogen bond (O-H…O). π-π intermol. interactions existed between the Ph and pyrazolone rings with 3.54 Å separation The prominent features were catalyst-free, green protocol, simple work-up, rapid synthesis, excellent yields and no column chromatog.3-Hydroxybenzaldehyde(cas: 100-83-4Product Details of 100-83-4) was used in this study.
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Product Details of 100-83-4
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