Zu, Han; Zhang, Hui; Fan, Anwen; Gu, Jie; Nie, Yao; Luo, Pengjie; Xu, Yan published the artcile< Highly efficient synthesis of (R)-1,3-butanediol via anti-Prelog reduction of 4-hydroxy-2-butanone with absolute stereoselectivity by newly isolated Pichia kudriavzevii>, Application of C4H10O2, the main research area is butanediol asym reduction hydroxybutanone stereoselectivity Pichia biosynthesis sequence.
(R)-1,3-butanediol is an important pharmaceutical intermediate, and the synthesis of (R)-1,3-butanediol using green biol. methods has recently been of interest for industrial application. Here, a novel strain QC-1 that efficiently transforms 4-hydroxy-2-butanone to (R)-1,3-butanediol was isolated from soil samples. Based on morphol., physiol., and biochem. tests and 5.8S-internal transcribed spacer sequencing, the strain was identified as Pichia kudriavzevii QC-1. The reaction conditions were optimized to 35°C, pH 8.0, rotation speed 200 rpm, and 6:5 mass ratio of glucose to 4-hydroxy-2-butanone. Evaluation of the effects of 4-hydroxy-2-butanone concentrations on yield and cell survival rate showed that 85.60 g·L-1 product accumulated, with an enantiomeric excess of more than 99%, when 30 g·L-1 4-hydroxy-2-butanone was added at 0, 10, and 30 h in a 3-L bioreactor. Thus, strain QC-1 showed excellent catalytic activity and stereoselectivity for the synthesis of (R)-1,3-butanediol from 4-hydroxy-2-butanone.
Chinese Journal of Chemical Engineering published new progress about Concentration (condition). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Application of C4H10O2.
Referemce:
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Alcohols – Chemistry LibreTexts